The Garuda River is one of the tributaries of Bengawan Solo in Sragen Regency which is suspected of experiencing a decline in water quality. This study aims to determine the quality and Pollution Load Carrying Capacity (PLCC) of the Garuda River to the source of pollutants, especially those caused by tofu industrial liquid waste. The research method used in this study is a quantitative method to analyze the status of river water quality using the Pollution Index (PI) method and the calculation of river PLCC using the QUAL2Kw model with 3 modeling scenarios. The analysis showed that the Garuda River was proven not to meet the class III quality standards because several parameters such as temperature, TSS, Nitrite (NO2-N), and Total Coliform were above the set quality standards. Based on the calculation of the Pollution Index, it was found that the Garuda River was proven to be polluted with a lightly polluted quality status with a pollution score ranging from 1.49 to 2.91. Based on QUAL2Kw modeling, it was found that the PLCC of Garuda River for TSS parameters was 233.28 – 259.20 kg/day, BOD was 12.96 – 15.55 kg/day, and COD was 51.84 – 103.68 kg/day. One of the control efforts that can be carried out is reducing the pollutant burden on each source of pollution, especially point source pollutants from tofu industrial liquid waste.