Palm Oil Mill Effluent (POME) can made into biogas. Acidogenesis as a fermentation process, where the hydrolysis products into simpler organic products in the form of acetate, hydrogen and carbon dioxide. Intermediate products from acidogenesis form of volatile fatty acids (VFA), such as propionate, butyrate, valerate, and their isoforms, require further metabolic processes to produce biogas. The aim of the research was to determine the suitable kinetics model that describe microbial growth (from Volatile Suspended Solid (VSS) values) and production in the acidogenesis process. The reactor used in this acidogenesis process is a stirred tank reactor with a volume of 6 L and operates in a batch system. This research was conducted with a variable agitation rate variation (200; 250; and 300 rpm); temperature (30ºC and 55ºC). The pH was varied 5; 5.5; and 6. The kinetic models used in this study were Modified Gompertz, Monod, and Logistic. The best effect of pH on VSS was obtained at pH 5.5, agitation rate on VSS was obtained at agitation rate of 250 rpm and operating conditions for acidogenesis process was achieved under thermophilic conditions (55oC). Logistic kinetic model is the best kinetic model that can describe VSS and VFA in this study.