Contamination caused by pharmaceuticals is recognized as one of the most severe forms of environmental pollution. Many medicines and medical waste are dumped on the land, especially near hospitals, medical clinics, stores, and others, so the aim of the study. The physical, and mechanical of soil properties and tetracycline in leachate were studied. The sample extractor device (Shelby tube) was used to take samples of undisturbed samples with a number of (6) tetracycline solutions added to the soil samples periodically. for a period of 6 months sample, every month. from results were noted silty clay is a type of this soil, the unconfined compression strength decreases with months to 6 months, while the effect on Atterberg’s limits (liquid and shrinkage limit) were shown the soil to become softer lowering the value of the liquid limit. the tetracycline test in leachate water decreased with time, due to the soil adsorbed tetracycline. first-order is suitable for the kinetic model. Finally, the tetracycline drug effect physical and mechanical soil properties.