The present study aimed to assess the potential health risks to the population of the Guelma region associated with the consumption of seafood products in the context of possible marine metal contamination with five heavy metals (Cd, Cu, Cr, Fe, and Ni) in the muscle tissues of 11 commercially important seafood species sampled from the eastern Algerian coast, and representing different taxonomic groups, namely mollusks, crustaceans, and fish. The samples were analyzed for heavy metals using a flame atomic absorbance spectrophotometer of the Perkin Elmer precisely AAnalyst 400type. The application of PCA revealed significant differences in metal accumulation among aquatic organisms. Mollusks were identified as the most contaminated group, confirming their suitability as bioindicators of environmental pollution. Fish exhibited the lowest levels of contamination, while crustaceans showed a specific affinity for copper. THQ, HI, and CR were assessed for both adults and children. The results highlighted that exposure doses of most elements for human consumption were within the threshold limit, and consequently were safe for non-carcinogenic and carcinogenic health risks.