The scientifically substantiated “dose-effect” relationship suggests that air pollutants increase the risks of reducing the population lifespan, especially in the industrialized areas and urban ecosystems. A characteristic manifestation of such negative impact consequences is an increase in the level of the population incidence rate and, as a consequence, shortening the lifespan. The paper evaluates and analyzes the impact of air pollution on the Odessa population lifespan. The influence of the city priority air pollutants on the lifespan of the population in the areas of the stationary observation points was considered. Based on the results of assessing the risk of being in the polluted air conditions for three age categories for each observation point, the hazard categories of individual pollutants were determined. In general, of all the pollutants in the air basin of Odessa, the content of carbon monoxide and phenol has the greatest impact on shortening the lifespan of the population.