Due to agricultural productivity being constrained by soil salinisation and scarcity of irrigation, especially in arid/semi-arid regions of Morocco, quinoa (Chenopodium quinoa Willd.), due to its ecological adaptability, provides a great alternative option. This study aims to evaluate the effect of salt stress on the agro-morpho-physiological and biochemical behaviour of the ICBA-Q5 variety under controlled greenhouse conditions representative of semi-arid environments. Four concentrations of NaCl (0, 3, 5 and 8 g·L⁻¹) were applied and the impact was monitored on germination as well as on agro-morphological and biochemical parameters. The results show a marked sensitivity of germination to salinity: the rate decreases from 100% in the control to 40% at 8 g·L⁻¹. Growth parameters are also affected, but less pronounced than germination, suggesting an ability to adjust after establishment. Furthermore, the increase in chlorophyll and proline content (PC) indicates the activation of adaptation mechanisms, consistent with osmotic adjustment in response to stress. These results help to clarify the potential of ICBA-Q5 for growing quinoa under saline conditions in eastern Morocco.