The presence of weeds in a cereal field is detrimental to the crop on several levels. The discovery of natural herbicides represents a potential solution for reducing the harmful effects on the environment. In this context, three plant species have been selected to assess their allelopathic potential: Marrubium vulgare, Dittrichia viscosa and Eucalyptus camaldulensis. The aim is to test their effectiveness as natural herbicides, by studying their influence on the germination and development of seedlings of certain weeds present in wheat crops. Aqueous leaf extracts at concentrations of 5% and 10% were prepared for each species. These extracts were applied to the seeds of four weed species (Avena sterilis, Phalaris brachystachys, Biscutella auriculata, Centauria melitensis) and to a variety of durum wheat, Triticum turgidum (Karim variety). The results show that both concentrations have a significant effect on seed germination and seedling growth compared with the control. Inhibition increased with extract concentration, although this response varied according to the plant species used. At 10%, Dittrichia viscosa extract inhibited Avena sterilis seed germination and growth by over 81%, a greater effect than that observed with Eucalyptus camaldulensis and Marrubium vulgare, which showed inhibition of over 75%. In contrast, Marrubium vulgare extract proved particularly effective against Phalaris brachystachys, with germination inhibition reaching 100%. Phytochemical analysis of the aqueous extracts revealed the presence of secondary metabolites such as flavonoids, glycosides, terpenes and saponins…. These bioactive compounds, notably those contained in Dittrichia viscosa and Marrubium vulgare, could be promising new bioherbicides against certain wheat weeds. Key words : Allelopathic, Inhibition, Bioherbicide, Bioactive compounds, Weeds .