This study aimed to develop an analytical model to justify the transition to nature-oriented farming, taking into account the spatial, economic, and soil characteristics of different regions. Comparative scenario modelling was carried out, comprising a baseline traditional agroscenario and an alternative system that incorporated biologisation of crop rotation, reduced agrochemical load, and an improved humus balance. The results showed that the alternative scenario increased yields by 3.4 centners per hectare and profitability by 17.5%, while simultaneously reducing per-hectare costs by 12.3%. The agrochemical load in this system was almost halved, and the humus balance reached a positive value of +0.48 tonnes per hectare. An original formula for ecological and economic efficiency (EEE) was proposed, allowing productivity, profitability, resource expenditure, and the ecological condition of soils to be synthesised into a single aggregate indicator. According to this formula, efficiency scores for three enterprises under the baseline scenario ranged from 8,000 to 10,800 points, whereas under the alternative scenario, they reached 11,780 to 15,867 points, indicating a substantial increase in efficiency. Spatial modelling of biologisation was also performed, which demonstrated the highest proportion of nature-oriented crops in the Polissia zone. A visual model of the interrelations “enterprise – technology – land – effect” was constructed, enabling the identification of key dependencies in sustainable agricultural production. The findings can be applied in making strategic decisions at the level of national agricultural policy.