Laboratory waste that is disposed of into the environment will have an impact on environmental pollution and threaten human health. Efforts to treat laboratory wastewater must be carried out. This research aims to analyze the effectiveness of Anaerobic Bioaccumulation Systems with sulfate reducing bacteria (SRB) in reducing heavy metals and sulfate ions as well as the effectiveness of Plant Biofiltration (PB) in reducing Biological Oxygen Demand (BOD), Chemical Oxygen Demand (COD) and heavy metals in laboratory wastewater compared to quality standards. In this research a plant biosystem which uses the principle of phytoremediation is used to reduce the heavy metal content in wastewater. This anaerobic reactor is cylindrical with r of 0.23 m and t of 0.93 m and has a volume of 1.5 m3. In this tank there is a SRB initial growth column with a volume 6.7 L. SRB media in the form of 30% compost fermentation solution, Postgate B nutrients with 10% sulfate added to the column. It stimulated with SRB seeds that had been isolated previously, then laboratory waste is added until it fills the column. After being acclimatized for 15 days, the laboratory wastewater began to flow slowly into Anaerobic Bioaccumulation System. The next stage is a plant filtration system in sized of basin 3 m x 1 .0 m x 1.0 m with of 4 vertical layers. The bottom layer consists of 20% limestone, 30% coral and 50% sand. The plant used is Sansevieria trifasciata. The research results showed that the SRB Anaerobic Bioaccumulation was effective in reducing heavy metals and sulfate ions by up to 80.6% with a residence time of 24 hours after growing SRB for 15 days PB is effective in reducing BOD, COD and heavy metal content to meet the specified quality standards with a residence time of 30 hours after plant acclimatization for 15 days. The combination of the SRB Anaerobic Accumulation and PB system worked effectively with a total residence time of 2.25 days, which was marked by a decrease in all test parameters to below the specified quality standards.