Poultry slaughterhouse wastewater (PSW) is a highly polluted effluent with a significant organic load, posing environmental challenges for treatment. This study investigates the potential of Bacillus cereus TD5B to grow and reduce organic matter in PSW. Laboratory-scale experiments were performed to assess the growth of Bacillus cereus TD5B in a PSW-containing medium and to evaluate the effectiveness of this bacterial strain in reducing key parameters, including biological oxygen demand (BOD5), chemical oxygen demand (COD), total solids (TS), total volatile solids (TVS), total suspended solids (TSS), total dissolved solids (TDS), and ammonium concentration. Bacillus cereus TD5B exhibited growth in both liquid and solid mediums containing PSW. The highest bacterial growth in liquid medium occurred in T1 (25% PSW), while in solid medium, T4 (100% PSW) showed the highest growth (5.1±0.8×10⁷ CFU/mL). The survival ability of Bacillus cereus TD5B following incubation in a medium supplemented with nutrients and PSW at varying concentrations was confirmed through viability assays and was evidenced by the expansion of colony diameter, with the largest colony diameter observed in T2 (50% PSW). Bacillus cereus TD5B effectively decomposed organic matter, significantly reducing several parameters assessed. The highest performance was observed in T4 (100% PSW), which achieved removal effectivity of 92.54±5.53% for BOD5, 51.28±14.84% for COD, 27.40±6.66% for TS, 70.53±14.84% for TVS, 88.49±4.51% for TSS, 22.45±7.30% for TDS, and 63.38±21.48% for ammonium. These findings suggest that Bacillus cereus TD5B holds promise as a bioremediation agent for treating high-content organic wastewater, such as PSW. Further research is recommended to optimize the conditions for bacterial growth and enhance performance in large-scale applications.