Pharmaceuticals and personal care products (PPCPs) are increasingly used worldly and become necessary for medicinal purposes and to enhancing quality of life. Over the three past decades are received attention as emerging pollutants due to their extensive applications and persistent emissions and capability to cause physiological effects in humans even in low concentrations. Accordingly, one of the main aims of this research was to detect for a list of PPCPs that could be existed in raw and treated wastewater in Columbia Wastewater Treatment Plant (CWWTP) using Chromatography mass spectrometry online platform (XCMS). The investigation process applied for selected putatively of 61 compounds for literatures and through the analyzing by XCMS. A total of 29 PPCPs putatively detected and listed for further analysis. The removal efficiency of PPCPs were illustrated large variability, depending on various factors such as physiochemical properties of molecules, mixing and dilution of wastewater matrices during high discharge particularly during raining seasons, retention time (RT), polarity and hydrophobicity. The results showed that the removal efficiency was variable clearly ,for instant , antibiotic class recorded( -236.3 to 97.6%) , for NSAID recorded (-53.9 to 84.3%),for stimulant (-6.9 to 99.7%) and other PPCPs were recorded different removal efficiencies like Ritonavir 63.6% ,prednisolone 73.7% ,while DEET, and Triclosan recorded, 56.3% and -81.7% ,respectively .The CWWTP demonstrated prefect removal for Azithromycin, Tolfenamic acid, 1,7-Dimethylxanthine, Caffeine, Cotinine and Morphine with average > 95%.Different treatment processes including, adsorption onto solid particles, precipitation process and biological degradation govern the PPCPs removal. Different relationships and parameters were considered regarding overall removal, for instance, the direct relationship between higher (logKow) and sorption to activated sludge due to hydrophobic nature of PPCPs will increase removal efficiency of these compounds through partitioning to solid phase. Conversely, pka could have an impact on sorption and biodegradation due to the ionization state of PPCPs compounds because the signal charged the compound will show reduce in sorption of these ions to the solid particles of sludge compared to their neutral counterparts. Consequently, these interacting mechanisms and physiochemical factors, lead to a wide variability in overall removal efficiency which were already computed based on relative intensities of PPCPs ion molecules.