This study aims to assess the removal efficiency of nine pharmaceutical compounds along with COD, BOD₅, nitrate (NO₃⁻), and phosphate (PO₄³⁻). Results showed that the removal of antibiotics—sulfamethoxazole, erythromycin, and ofloxacin—ranged from 30–34% in the HWWTP, and lab-scale MBR achieved significantly higher rates, between 60–78%. For non-steroidal anti-inflammatory drugs such as diclofenac, paracetamol, and ibuprofen, the HWWTP removed 35–54%, compared to 53–81% in the lab-scale system. Compounds like carbamazepine, diazepam, and furosemide showed modest removal in HWWTP (11%, 20%, and 34%, respectively), but improved performance in MBR (31%, 39%, and 45%). The tubesettler alone contributed to pollutant removal in the range of 15–31% in HWWTP and 24–51% in the lab-scale setup, suggesting its potential as a polishing step when used alongside an MBR. Future research should also investigate the impact of sudden chemical loads—such as surfactants and disinfectants on HWWTP performance.