The article presents the results of a three-year (2023–2025) field study. Its purpose was to investigate the effect of complexes of microbiological preparations and organo-mineral fertilizers with an anti-stress effect on the productivity of the SY Fregat maize hybrid in the Khmelnytskyi region on deep low-humus chernozem soil. The research compared three options for foliar treatment–biopesticides; biopesticides plus organo-mineral fertilizers; and biopesticides plus organo-mineral plus biodynamic preparations–against a control group. A highly reliable, statistically significant influence of all treatment options on the structural elements of the harvest and the total yield was established. The maximum yield was achieved using the integrated system (Treatment No. 3), which combined biological protection (Trichodermin, Planriz, Biplan, Bitoxibacillin, Lepidocid), organo-mineral nutrition (Shchedrodar), and biodynamic stimulation (Barrel compost, 500P), mainly due to the highest number and mass of grains per cob. However, the economic assessment (ROI) showed that Treatment No. 2 (biopesticides plus organo-mineral fertilizers) was the most profitable, providing the highest return on investment with a yield of 15.44 t ha-1. The study concluded that complex foliar nutrition (Treatment No. 2) is the most economically viable and effective technology for increasing the stability of maize production.