This study evaluates the phytogenic potential of Lablab purpureus leaf extract in enhancing growth performance and feed efficiency of Nile tilapia under Aeromonas hydrophila challenge. The research aimed to determine whether graded dietary inclusion of L. purpureus could improve growth, immune resilience, and metabolic efficiency during bacterial stress. A controlled feeding trial was conducted using a Completely Randomized Design with five treatments and three replicates, assessing key performance metrics including absolute length, weight, specific growth rate, and feed conversion ratio. Extracts were prepared through Soxhlet ethanol extraction and administered at 0.5%, 1%, and 2% inclusion levels. Results showed significant improvements in growth performance, particularly in the 0.5% and 2% groups, which exhibited superior weight gain, SGR, and feed conversion efficiency compared to the challenged control. The phytogenic extract appeared to mitigate pathogenic effects by enhancing digestive function, antioxidant activity, and immune modulation. Water quality remained stable, confirming dietary effects as the primary driver of observed differences. Overall, L. purpureus demonstrates strong potential as a sustainable alternative to antibiotics in aquaculture by improving growth, health, and resistance to A. hydrophila. Further research should explore long-term impacts, synergistic phytogenic combinations, and mechanisms underlying the bioactive effects.