Despite the creation of protected areas (PAs) in Peru, reports and research show that pressure and losses still exist in these same areas. The objective of this study was to analyze the relationship between changes in land use and land cover between 2011 and 2024 in the Huaytapallana Regional Conservation Area (HRCA). Data from MapBiomas and a multitemporal geospatial analysis were used. The results indicate a loss of forest (−508.68 ha), grassland (–4,975.02 ha), and glaciers (−6,682.5 ha), along with an increase in rocky outcrops (+11,719.89 ha) and scrubland (+6,329.34 ha), reflecting an accelerated process of aridification, deglaciation, and human pressure in the HRCA. These findings show that the ecological degradation of the HRCA and jeopardizes the functionality of the conservation area, highlighting the urgency of strengthening governance.