This research explores the utilization for adsorbents produced from agricultural waste (AW) and coconut shells (CS), that were chemically activated through the use of phosphoric acid (H₃PO₄) and potassium hydroxide (KOH), to evaluate their efficacy in eliminating acetaminophen (ACT) from water. Batch tests were carried out to assess the impact of operational parameters, including pH and adsorbent dose, initial ACT concentration, and contact time, on adsorption performance. Under optimal conditions - including a dose of 1.1 g/L, pH 8.0 for all modified adsorbents (except AW-H₃PO₄ at pH 4), a contact duration of 120-150 min, and ACT concentrations of 100 and 120 mg/L - a highest effectiveness of removing of 95% was attained.. Chemical modification of the raw materials considerably enhanced the surface area of the adsorbents, improving their adsorption capabilities. Adsorption behavior was further examined utilizing a variety of isotherm and kinetic models, with the pseudo-second order model providing the most accurate fit. Isotherm results indicated monolayer adsorption on heterogeneous surfaces. Langmuir analysis revealed a maximum capacity for adsorption of 10.07 mg/g of AW-H₃PO₄ and 9.699 mg/g for AW-KOH, surpassing the 5.102 mg/g capacity of unmodified agricultural waste. Similarly, modified coconut shell adsorbents showed improved capacities-11.416 mg/g for CS-H₃PO₄ and 10.549 mg/g for CS-KOH, compared to 4.831 mg/g for the unmodified one.