Introduction: Several studies have highlighted the importance of these 3 concepts, which are probiotics, prebiotics and symbiotic in daily clinical practice. They play an important role in the treatment/prevention of several diseases and contribute to the proper functioning of the digestive and immune systems. Objective:The objective of our study is to describe and compare the evolution of the use of symbiotic by the Moroccan population based on the sales rate between the year 2020 and 2021.Methods:Data collection was carried outby a means of a questionnaire concerning 15 symbiotic products most used by the Moroccan population. Results: Our study suggests that some products have seen an increase in sales between 2020 and 2021, such as Lactobaciluscasei which reached 95,500 products in 2021 instead of 69,500 products in 2020,while the sale of the products decreased such as Bifidobacteriumlongum which reached 0 products in 2021 instead of 300 products in 2020, and according to the student test there is a significant difference between the average sales during the two successive years of 2020 and 2021(p=0,037).Conclusion:Ourresults show that the consumption and the use of symbiotic products by Moroccan populationhave shown significant differences. Keywords: Symbiotic, prebiotics, probiotics, sales, Moroccan population.