This paper presents a model of dynamics control for continuous stirred tank reactor (CSTR) in methanol synthesis in a three-phase system. The reactor simulation was carried out for steady and transient state. Efficiency ratio to achieve maximum performance of the product per reactor unit volume was calculated. Reactor dynamics simulation in closed loop allowed to received data for tuning PID controller (proportional-integral-derivative). The results of the regulation process allow to receive data for optimum reactor production capacity, along with local hot spots eliminations or temperature runaway.