Pharmaceutical contaminants are difficult to remove with standard treatment techniques and are one of the current problems in wastewater treatment. These bioactive substances are considered emerging pollutants due to their persistence and potential impact on aquatic ecosystems. Even in small amounts, they will continue to function. Efficient wastewater treatment methods are needed to address this issue. As a result, efforts to develop more efficient wastewater treatment methods have recently intensified. Fluidized bed reactors offer a special opportunity for efficient treatment of wastewater containing recalcitrant pollutants. This article discusses FBBR and covers its advantages, disadvantages, modifications, and applications. Additionally, the FBBR design is briefly discussed.