A key indicator of methane fermentation process which influences the cost-effectiveness of the biogas plant is efficient production of methane per 1 m³ of reactor. It depends on a proper selection of environmental and process parameters. This article present collected and analyzed effect of most important parameters of continuous methane fermentation (CSTR), which include temperature, pH, nutrient content and the C/N ratio in the feed medium, the presence of inhibitors, and the volume load of reactor, retention time and mixing of digestion reactor. Still, the impact of many factors remain unknown, hence there is a need for more comprehensive studies.