In the modern technological processes, the microfiltration membranes are used for removal of the suspended particles, colloids and microorganisms from the liquid solutions, as well as for use of the biologically active substances. Their demand at the world market rises day by day and if their production from the polymeric materials having wide range porosity, as well as high mechanical, thermal and chemical stability is provided the field of their use will expand even more. Proceeding from all above, fluoroplastic (F-4) was chosen, as the thermo- and chemically stable polymer used in medicine and food industry for production of the wide range porosity microfiltration membranes. The methods used for modification of membranes in the process of the research do not require any toxic solvents or complicated appliances or high power inputs. The thermo- and chemical stability of the produced membranes allows their multiple use in the process of filtration, which also allows implementing the principles of ,,green’’ technology. Pore sizes distribution of membranes was researched on Porometer by using the method of capillary flow porometry in compliance with the standards of ACTM F-316-03, which rules out using of the toxic (or hazardous substances), ex. mercury