The results of long-term research (2012 2022 in ongoing experiment) on podzolized black soil to study the effectiveness of the use of organic (manure, non-marketable part of the crop, siderate) and mineral fertilizing systems in short term crop rotation are presented. The positive effect of the use of organic fertilizers and non-marketable part of the crop on stabilizing the amount of humus, increasing the reserves of alkaline-hydrolyzed nitrogen, mobile phosphorus and potassium forms in the soil was established. Changes in the nutrient regime and agrochemical properties of podzolized black soil under different saturation of crop rotations with cultivated crops, grain crops and leguminous plants are shown. A significant impact on the nutrient regime of the soil in short-term crop rotations under crops of both the organic-mineral fertilizer system and its predecessors has been proven. It was established that the use of manure with mineral fertilizers (traditional organic-mineral fertilizer system) in crop rotation provides an increase in the content of nutrients in both arable and subarable layers of the soil, promotes an increase in the amount of crop residues, and, accordingly, organic matter, and provides a positive balance of nutrients under crops in crop rotation. The research materials are of practical importance for the implementation of nutrition optimization systems in short term crop rotations aimed at both sustainable increase of crop yields and maintenance and restoration of soil fertility.