The research focuses on the effect of solvent polarity on the quantity extracted, chemical composition, and antioxidant capacity of Lavandula multifida extracts. The extraction yields were 10.63 for hydroethanolic, 9.86 for aqueous, 7.90 for hydromethanolic and 7.00 for hydroacetonic, confirming the determining effect of solvent polarity. The levels of total polyphenols ranged from 26.3 mg Gallic acid equivalent per gram of dry to 12.08 mg EAG/g MS, while total flavonoids were the highest in the aqueous extract (25,35 mg EQ/g MS). Phytochemical screening revealed the presence of quinones, coumarins, flavonoids, alkaloids and tannins, with saponins detected only in the aqueous extract.2,2-diphenyl-1-picrylhydrazyl antioxidant activity showed Half maximal inhibitory concentration ranging from 145.44 μg/mL (aqueous) to 351.30 μg/mL (hydromethanolic), and the Ferric reducing antioxidant power assay revealed Epicatchin equivalents of 682.62 μg/mL (hydroethanolic) to 950.56 μg/mL (hydroacetonic). Optimization by D-optimal and Response Surface Methodology led to the definition of ideal conditions for increasing the concentration of polyphenols and flavonoids during extraction. These data highlight the pharmacological and antioxidant properties of L. multifida and provide a reliable methodology for the targeted extraction of bioactive compounds. Keywords Lavandula multifida, secondary metabolites, polyphenols, flavonoids, antioxidant activity, D-optimal, Response Surface Methodology