Biofilm processes are increasingly being recognized for the removal of organics and nutrients in domestic wastewater treatment. One system that is often used is the Fixed-Bed Reactor (FBR). This review aimed to analyze wastewater treatment using anoxic-aerobic FBR system with various supporting media. The method used was the descriptive analysis of articles obtained from Google Scholar, ScienceDirect, and Springer. The results of the review showed that wastewater treatment with a growth system is able to remove organics and nutrients quite high. The types of polymers used as supporting media for attaching biofilms consisted of PET, PS, HDPE, and LDPE. However, when viewed from the removal efficiency, the supporting media with polymers is superior to PET compared to other types. This is because PET has hydrophobic physicochemical properties which have good adhesion in the initial attachment of microorganisms. In addition, this type of PS polymer also has fairly high organic and nutrient removal efficiency, similarly to other types of polymers such as HDPE, and LDPE.