The symbiotic have been shown to be effective in prophylaxis and treatment of various diseases. Indeed, one of the main functions of probiotics is to improve microbial homeostasis in the body and to decrease the invasion of pathogens and their colonization. Objective: The objective of our study is to assess and then compare the rate of sales and the use of symbiotics by the Moroccan population in order to describe the status of sale of this type of Medicine. Methods : The collection of belly data was carried out using a questionnaire which contains information on all Moroccan market products and this study includes fifteen of the most widespread symbiotics products (probiotics and prebiotics). Results : Our study suggests that the sale of symbiotic products increased in some strains such as bacterial strain Bifidobacterium infantis which reached 96,300 units and Bifidobacterium lactis with a sale which reached 35,000 units and also there was also a decrease in sales of other symbiotic products such as Lactobacillus casei in 2019 compared to the sale in 2018 and according to the student test there is no significant difference between the average sales during the two successive years of 2018 and 2019 (P=0.496). Conclusion : Our results show that the consumption and use of symbiotic in Morocco has undergone significant fluctuations trending towards a regression.